Abstract #2393
Edited MRS of the Infant Brain on 28 Scanners
Saipavitra Murali-Manohar1,2, Helge J. Zöllner1,2, Christopher W. Davies-Jenkins1,2, Aaron T. Gudmundson1,2, Steve C.N. Hui3,4,5, Yulu Song1,2, Borjan Gagoski6,7, M. Dylan Tisdall8, Muhammad G. Saleh8,9, Kimberly B. Weldon10, Jens T. Rosenberg11, Ralph Noeske12, William T. Clarke13, Georg Oeltzschner1,2, Jessica L. Wisnowski14,15, and Richard A.E. Edden1,2
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Developing Brain Institute, Children’s National Hospital, Washington D.C., DC, United States, 4Departments of Radiology, The George Washington University School of Medicine and Health Sciences, Washington D.C., DC, United States, 5Departments of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington D.C., DC, United States, 6Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, 7Department of Radiology, Harvard Medical School, Boston, MA, United States, 8Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 9Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 10Masonic Institue for the Developing Brain, University of Minnesota, Minneapolis, MN, United States, 11Advanced Magntic Resonance Imaging and Spectroscopy Facility, McKnight Brain Institue, University of Florida, Gainesville, FL, United States, 12GE HealthCare, Munich, Germany, 13Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 14Department of Radiology and Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States, 15University of Southern California, Los Angeles, CA, United States
Synopsis
Keywords: Spectroscopy, Data Analysis, Neonatal, Data Acquisition, Data Processing
Motivation: The Healthy Brain and Child Development (HBCD) study is a longitudinal, multi-vendor, multi-site study of early brain development, which will enroll ~7,500 infants. HBCD includes MRS within the imaging protocol.
Goal(s): The goal of this abstract is to present HBCD MRS pilot data, and identify any vendor and site differences in MRS data quality and measured metabolite concentrations.
Approach: HBCD pilot MRS data were successfully acquired on 28 scanners, and analyzed using Osprey 2.5.0, to examine vendor and site differences.
Results: ANOVA results show minimal vendor and site differences which is encouraging for such a large-scale multi-site, multi-vendor study.
Impact: HBCD is an NIH-funded multicenter study of brain development across the first decade of life. It is the largest ever study to incorporate MRS. In this abstract, we present in vivo data demonstrating MRS performance across vendor and site.
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