Abstract #2397

Amide proton transfer MRI-based radiomic signatures for molecular subgrouping of pediatric medulloblastoma

Junjie Wen¹, Hongxi Zhang², Xiaohui Ma², Xinchun Chen², Weibo Chen³, Feng Zhao⁴, Kannie W. Y. Chan⁵, Zhipeng Shen⁶, and Yi Zhang¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China, ²Department of Radiology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, ³Philips Healthcare, Shanghai, China, ⁴Department of Radiation Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, ⁵Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ⁶Department of Neurosurgery, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

Synopsis

Keywords: Cancer, Radiomics

Motivation: Medulloblastoma (MB) is classified into different molecular (WNT, SHH, Group 3, and Group 4) subgroups. Accurate identification of molecular subgroups provides clinical value to the diagnosis of MB.

Goal(s): We aim to combine APT MRI and radiomic analysis to establish signatures for distinguishing molecular subgroups of pediatric medulloblastoma.

Approach: Fifty newly diagnosed pediatric patients with medulloblastoma were enrolled in this study. Radiomic features were extracted from APT-related metrics to differentiate MB subgroups.

Results: APT MRI-based radiomic signatures exhibited favorable performance in identifying WNT, SHH, Group 3, and Group 4 subgroups with AUCs ≥ 0.91.

Impact: Our research findings demonstrate that amide proton transfer MRI-based radiomic analysis offers a noninvasive and cost-effective method to distinguish molecular subgroups and holds great potential in providing valuable clinical insights for the diagnosis of pediatric medulloblastoma patients.

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