Keywords: Structural Connectivity, Cancer
Motivation: Cognitive impairment following treatment of medulloblastoma has been associated with white matter structural changes and altered structural brain connectivity.
Goal(s): We hypothesized that decreased intensity therapy would reduce acute change in the working memory structural connectome.
Approach: Working memory structural connectomes were assessed relative to baseline after 15 Gy craniospinal irradiation (RT), after subsequent reduced-intensity chemotherapy, and during follow-up for 24 children treated for WNT-subtype (WNT) medulloblastoma.
Results: Changes after RT or chemotherapy showed small increases in connectivity strength in frontal striatal edges indicating little acute change. Follow-up revealed significant decreases in connectivity of the bilateral connections between caudate/thalamus.
Impact: Increased connectivity of frontal striatal edges after therapy and decreased connectivity of caudate/thalamus edges in follow-up for patients receiving reduced intensity therapy for WNT medulloblastoma may indicate a low incidence of acute changes.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords