Abstract #2405

Comparison of water exchange measurements between filter-exchange and diffusion time-dependent kurtosis imaging in human brain

Zhaoqing Li¹, Thorsten Feiweier², Yi-Cheng Hsu³, and Ruiliang Bai^1,4,5

¹Department of Physical Medicine and Rehabilitation of the Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China, ²MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, ³MR Research Collaboration Team, Siemens Healthineers Ltd., Shanghai, China, ⁴Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang university, Hangzhou, China, ⁵MOE Frontier Science Center for Brain Science and Brain-machine Integration, School of Brain Science and Brain Medicine, Zhejiang university, Hangzhou, China

Synopsis

Keywords: DWI/DTI/DKI, Brain, Trans-membrane water exchange; FEXI; time-dependent DKI; in vivo

Motivation: Trans-membrane water exchange rate has been measured by several MRI methods but reported with largely variant results.

Goal(s): To explore whether Filter-exchange imaging (FEXI) and time-dependent DKI are comparable for water exchange measurements on the same subjects in human brain.

Approach: Eight healthy volunteers underwent FEXI and DKI(t) acquisitions on a 3T scanner. ROI-based analysis was performed to determine correlations between FEXI-derived AXR and DKI(t)-derived 1/τ_ex.

Results: A significant correlation between AXR and 1/τ_ex was found only in axial direction in white matter. This correlation should be interpreted cautiously because structural disorder has non-negligible effects on D(t) and K(t) in Kärger model.

Impact: While a significant correlation was observed between AXR and 1/τ_ex in the axial direction, this study suggests cautious use of DKI(t) for water exchange measurements due to potential deviations from the Kärger model's constant diffusivity assumption in the human brain.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.