Keywords: Diffusion Software, Software Tools, High-throughput, Docker, Reproducibility, Autism Spectrum Disorder, Brain Connectivity
Motivation: The complex whole brain connectome is underlined by white matter (WM) fibers featuring both long and short-range connections. Most existing protocols are tailored to trace long-range fibers, incapable of comprehensively tracing all fibers including both long and short-range fibers.
Goal(s): To achieve comprehensive mapping of whole-brain WM fibers in a unified framework including specifically high-fidelity tractogram of short-range fibers.
Approach: We developed DEPTH, a Docker-containerized pipeline extending advanced short-range fiber tracing.
Results: DEPTH offers high-throughput, reproducible and comprehensive tractogram of both long and short-range WM fibers. The Docker-based containerization ensures cross-platform usability and versatility without complex setup and configuration.
Impact: High-throughput, reproducible and comprehensive whole-brain white matter fibers across multisite datasets could now be traced by our software.
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