Keywords: Diffusion Acquisition, Diffusion/other diffusion imaging techniques, eddy currents, image distortion, time-optimal
Motivation: Eddy current-induced image distortions in DWI require either tedious image-based corrections or time inefficient pulse sequence acquisitions that increase the minimum echo time (TEmin) and limit SNR.
Goal(s): Pre-excitation gradients for eddy current-nulled convex optimized diffusion encoding (Pre-ENCODE) was used to mitigate eddy current-induced image distortions without increasing TEmin.
Approach: Simulations, phantoms, and volunteer DWI with monopolar (MONO), eddy current-nulled convex optimized diffusion (ENCODE), and Pre-ENCODE were used to evaluate TEmin, eddy current-induced image distortions, and ADC.
Results: Pre-ENCODE offers shorter TEmin compared to MONO and ENCODE as well as reduced eddy current-induced image distortions and more accurate ADC values compared to MONO.
Impact: Pre-ENCODE reduces eddy current-induced image distortions by incorporating an additional pre-excitation gradient. Pre-ENCODE provides a shorter TEmin, increased SNR, improved image registration, and more accurate ADC quantification compared with conventional DWI encoding techniques.
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