Abstract #2462

Quantitative susceptibility mapping of brain iron predicts onset of mild cognitive impairment and cognitive decline

Lin Chen^1,2, Anja Soldan³, Andreia Faria¹, Marilyn Albert³, Peter van Zijl^1,2, and Xu Li^1,2

¹Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Neurology, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: Susceptibility/QSM, Quantitative Susceptibility mapping, cognitive decline

Motivation: Brain iron content may play an important role in the development of Mild Cognitive Impairment (MCI) and dementia due to Alzheimer’s Disease (AD).

Goal(s): To investigate the utility of baseline brain iron levels, measured by quantitative susceptibility mapping (QSM), to predict time to onset of symptoms of MCI and global cognitive decline among older adults with normal cognition at baseline.

Approach: Cox regression models and linear mixed models were used.

Results: Higher brain iron levels in entorhinal cortex and putamen were associated with an earlier time to MCI onset and greater global cognitive decline, independent of the volume and amyloid of those regions.

Impact: Brain iron deposition assessed by QSM MRI may help predict risk of MCI onset and cognitive decline among cognitively normal individuals.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.