Keywords: Neurofluids, Neurofluids
Motivation: Perivascular space (PVS) is a pial-lined, fluid-filled structure that accompany penetrating arteries or draining veins from the cerebral cortex. PVS occupies a large portion of the cerebral tissue. The effect of PVS on the brain's functional connectivity has not yet been fully investigated.
Goal(s): In particular, our goal was to determine the link between PVS, sleep and brain functional connectivity.
Approach: We utilized the structural MRI and rs-fMRI data from the HCP-Aging dataset.
Results: Results demonstrated that BG-PVS volume fraction was positively associated with FC of the right anterior medial temporal gyrus and a cluster in temporal regions.
Impact: These findings suggest that PVS morphology may reflect changes in neural connectivity involved in memory-related processing and open a new PVS research field (structure to function) for investigation.
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