Keywords: Blood Vessels, Velocity & Flow, Neuro, Hypoxia, Oxygenation, Cerebrovascular Reactivity
Motivation: The cerebrovascular response to mild hypoxia has not been well-characterized, but hypoxic cerebrovascular reactivity (CVR) may be an important metric that could complement hypercapnic CVR in clinical applications, giving distinct information about cerebrovascular health.
Goal(s): We aimed to increase reliability of hypoxic CVR and modulate the effects of concurrent CO2 changes.
Approach: Using phase-contrast MRI, we measured cerebral blood flow during baseline, hypoxic, and hypercapnic respiratory states, induced with a computer-controlled gas blender. We used hypercapnic CVR to implement a simple correction for changes in PETCO2 that occurred during hypoxia.
Results: While substantial inter-subject variability remained, PETCO2 correction reduced variability and improved reliability.
Impact: Minimizing and correcting for concurrent changes in PETCO2 during a mild inhaled hypoxic stimulus improves the reliability of hypoxic cerebrovascular reactivity, but normal inter-subject variability and the utility of hypoxic cerebrovascular reactivity in clinical populations have yet to be determined.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords