Abstract #2497

Altered topological properties of morphological and functional brain networks in patients with NMOSD: An individual-based study

Haotian Ma^1,2, Yanyan Zhu¹, Lin Wu¹, Yao Wang¹, Xiao Liang¹, Xiaoxing Li¹, Long Qian³, Gerald L. Cheung⁴, Jiankun Dai⁵, and Fuqing Zhou^1,6

¹Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China, ²Queen Mary School, Nanchang University, Nanchang, China, ³Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China, ⁴Spin Imaging Technology Co Ltd, Nanjing, China, ⁵MR Research, GE Healthcare, Beijing, China, ⁶Neuroimaging Laboratory, Jiangxi Medical Imaging Research Institute, Nanchang, China

Synopsis

Keywords: Neuroinflammation, Neuroinflammation

Motivation: Alterations of brain structure and function in patients with neuromyelitis optica spectrum disorder (NMOSD) are not fully understood.

Goal(s): To assess the alteration of individual brain network topological properties and their clinical significance in NMOSD.

Approach: 18 NMOSD patients and 22 healthy controls were enrolled. Individual morphological (MBNs) and functional brain networks (FBNs) were created and compared.

Results: The results revealed compensatory increases in local network properties in NMOSD to maintain overall stability. The MBNs showed more significant changes and stronger correlations with clinical information than FBNs.

Impact: Our findings provided insights into NMOSD's complex neurological mechanisms from a brain network perspective and revealed the clinical significance of MBN and FBN in patients with NMOSD.

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