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Abstract #2505

Targeted MRI (tMRI) of Small Changes in the T1 of White Matter of the Brain in Methamphetamine Dependency Before and After Abstinence.

Paul Condron1,2, Gil Newburn1, Eryn Kwon1,2,3, Taylor Emsden1,2, Benjamin Bristow1,2, Maryam Tayebi1,2, Tuta Ngarimu4, Wendy Mohi1, Samantha J Holdsworth1,2, Daniel Cornfeld1,2, Miriam Scadeng1,2, and Graeme M Bydder1,5
1Mātai Medical Research Institute, Gisborne, New Zealand, 2The University of Auckland, Auckland, New Zealand, 3Auckland Bioengineering Institute, Auckland, New Zealand, 4Manaaki Moves, Gisborne, New Zealand, 5University of California San Diego, San Diego, CA, United States

Synopsis

Keywords: Neuroinflammation, Drugs, tMRI, Methamphetamine recovery, WM recovery

Motivation: Targeted MRI (tMRI) of small changes in T1 in lesions in normal appearing white matter using divided Subtracted Inversion Recovery (dSIR) sequences can show high contrast and abnormalities that are not seen with conventional IR sequences.

Goal(s): To depict subtle changes in T1 in otherwise normal appearing white matter with dSIR images.

Approach: Applying tMRI in a patient with methamphetamine dependency before and eight months after abstinence.

Results: Widespread abnormalities on dSIR images in areas of normal appearing WM n T2-FLAIR images. There was striking remission of the changes after eight months' abstinence. The changes may be due to neuroinflammation regression with abstinence.

Impact: In a patient with methamphetamine dependency, tMRI using dSIR sequences showed striking abnormalities in white matter that appeared normal with T2-FLAIR sequences of the brain. These changes showed marked regression after eight months' abstinence.

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Abstract

Keywords