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Abstract #2532

4D Flow MRI in Pediatric Brain Arteriovenous Malformation: The Role of Hemodynamic Markers in Monitoring Disease Progression

Jonas Schollenberger1, Shivani Mahuvakar2, Christine K Fox3, Pratik Mukherjee1, Helen Kim4, Heather Fullerton3, and David Saloner1
1Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States, 2Neurological Surgery, University of California - San Francisco, San Francisco, CA, United States, 3Neurology, University of California - San Francisco, San Francisco, CA, United States, 4Anesthesia, University of California - San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Neuro, Velocity & Flow, Brain Arteriovenous Malformation

Motivation: Approximately 10-20% of pediatric patients with brain arteriovenous malformation (bAVM) present with reoccurring formation or growth even after initial successful treatment.

Goal(s): Evaluate the feasibility and efficacy of 4D Flow MRI to quantitatively assess the hemodynamic changes in pediatric bAVMs following treatment and establish its use for early detection of high-risk changes.

Approach: Prospective 4D Flow MRI study of pediatric bAVM patient cohort pre and post treatment

Results: Decreased flow rate and maximum velocity in main bAVM feeding arteries post treatment, resulting in reduced flow laterality mismatch between hemispheres.

Impact: 4D Flow MRI provides a quantitative tool to assess pediatric bAVM flow characteristics and the hemodynamic impact of intervention, which may help to identify patients at risk of bAVM reoccurrence.

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