Keywords: Elastography, Data Analysis, Brain, Liver, Inflammation, Neuroinflammation
Motivation: Obesity is associated with numerous debilitating diseases. Obesity-related conditions once only seen in adults are now being seen in children. Obesity affects numerous organs and may affect a child's ability to learn.
Goal(s): Identify changes in liver and brain stiffness measurements in the pediatric population that may indicate signs of early-stage disease.
Approach: MR elastography images of the liver and brain were obtained and compared to dual energy X-ray (DXA) metabolic measurements.
Results: Significant correlations between obesity and stiffness changes in the thalamus and amygdala were identified.
Impact: Preliminary results show that changes in liver and brain microstructure of the pediatric population can be seen in correlation to increased adiposity. MR elastography is a valuable tool in diagnosing those early changes.
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