Abstract #2548

Brain iron metabolism in neonates with hyperbilirubinemia by Quantitative Susceptibility Mapping

Yuanyuan Wang¹, Linfeng Yang², Tao Chen³, Xianglin Li¹, and Lingfei Guo⁴

¹School of Medical Imaging, Binzhou Medical University, Yantai, China, ²Department of Radiology, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China, ³Department of Laboratory medicine, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China, ⁴Department of Imaging, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China

Synopsis

Keywords: Neonatal, Brain, Brain iron metabolism

Motivation: The motivation of this study was to investigate the changes in brain iron metabolism in neonates with hyperbilirubinemia (NHB).

Goal(s): The goal was to assess the diagnostic value of QSM in NHB and explore its brain iron metabolism.

Approach: Clinical trial

Results: Brain iron content can dynamically change with serum bilirubin level in NHB, and brain iron content was significantly higher than that of healthy neonates in the putamen.

Impact: The QSM value of the putamen can accurately diagnose NHB, and provide early warning of brain injury.

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