Abstract #2555

Association with Maternal Diet Quality during Pregnancy and Neonatal Brain White Matter Development

Xiaoxu Na¹, Charles M. Glasier^1,2, Aline Andres^2,3,4, and Xiawei Ou^1,2,3

¹Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, United States, ²Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States, ³Arkansas Children’s Nutrition Center, Little Rock, AR, United States, ⁴Arkansas Children’s Research Institute, Little Rock, AR, United States

Synopsis

Keywords: Neonatal, Neuroscience

Motivation: Maternal nutrient intake is important for fetal growth and development.

Goal(s): This study examined associations between maternal diet quality during pregnancy and neonatal brain white matter development.

Approach: Forty-four healthy pregnant woman/newborn dyads were included in the study. The mothers had nutrition intake assessed by Healthy Eating Index-2015 (HEI-2015) throughout pregnancy. Correlations between neonatal MRI diffusion tensor imaging (DTI)-measured fractional anisotropy (FA) and HEI-2015 scores were evaluated.

Results: Significant correlations between maternal sodium intake at 1^st trimester of pregnancy and neonatal white matter FA values were found, indicating potential influence of maternal sodium intake during early pregnancy on neonatal brain white matter development.

Impact: We found significant correlations between maternal sodium intake at first trimester of pregnancy and neonatal DTI-measured FA values, indicating sodium intake better aligned with the Dietary Guidelines of Americans during early pregnancy is associated with better neonatal white matter development.

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