Keywords: Diffusion Modeling, Diffusion/other diffusion imaging techniques, hepatocellular carcinoma, intrahepatic cholangiocarcinoma, stretched-exponential model, fractional order calculus model
Motivation: The traditional apparent diffusion coefficient (ADC) value had limited value in differentiating hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).
Goal(s): To evaluate the value of stretched-exponential model (SEM) and fractional order calculus (FROC) diffusion model in differentiating HCC and ICC.
Approach: Parameters from SEM and FROC models and ADC value using multiple b-value DWI data were obtained, and were evaluated using t-test and ROC curve in differential diagnosis of HCC and ICC.
Results: Distributed diffusion coefficient (DDC) from SEM and diffusion coefficient (D) from FROC had significant differences between HCC and ICC, and had higher performances than the ADC.
Impact: DDC from SEM and D from FROC model may be helpful to improve the accuracy of the preoperative imaging diagnosis and guide personalized treatment for liver tumor.
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