Keywords: Diffusion Analysis & Visualization, Quantitative Imaging, Peripheral nerves, denervation
Motivation: Quantitative muscle MRI (qMRI) metrics (T2, diffusion diameter, and fat fraction (FF)) are sensitive to tissue microstructure, and altered in denervated muscle. However, the time-dependencies of these metrics as they relate to denervated muscle have not yet been analyzed in humans.
Goal(s): Assess patterns of qMRI changes in the lower extremity in denervated muscle.
Approach: Muscles from 24 lower extremity exams (23 patients) were categorized as non-denervated or denervated (chronically- or acutely-involved) using electromyography findings.
Results: Increased T2 in denervated muscles, and increased FF in chronically-involved muscles, and alternating patterns of diffusion diameter with time.
Impact: Quantitative MRI changes in lower extremity denervated muscles may complement peripheral nerve MRI and electromyography by providing tissue sensitive information relevant to the extent of disease at specific timepoints from initial injury.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords