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Abstract #2581

Correction of B0-related distortions in diffusion-weighted images of malignant and normal cervical tissue

Elin Lundström1,2,3, Ana E Rodríguez-Soto1, Christopher Conlin1, Stephane Loubrie1, Stephan Jordan1, Sheida Ebrahimi1, Alexandra Besser1, Alexandra Schlein1, Marianne Hom-Tedla4, Cheryl Saenz4, Shira Varon4, Michael McHale4, Michael Hahn1, Elisabeth Hedlund3, Björg Jónsdóttir5, Katarzyna Kozar3, Joshua Kuperman1, Tyler M Seibert1,6,7, Anthoula Koliadi8,9, Per Liss2,3, Anders Dale1,10, and Rebecca Rakow-Penner1
1Department of Radiology, University of California San Diego, La Jolla, CA, United States, 2Department of Surgical Sciences, Uppsala University, Uppsala, Sweden, 3Center for Medical Imaging, Uppsala University Hospital, Uppsala, Sweden, 4Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, CA, United States, 5Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden, 6Department of Radiation Medicine, University of California San Diego, La Jolla, CA, United States, 7Department of Bioengineering, University of California San Diego, La Jolla, CA, United States, 8Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, 9Department of Oncology, Uppsala University Hospital, Uppsala, Sweden, 10Department of Neuroscience, University of California San Diego, La Jolla, CA, United States

Synopsis

Keywords: Diffusion Software, Data Processing, distortion correction, cervical cancer, cervix

Motivation: DWI in cervical cancer evaluation suffers from distortions, especially pronounced by intestinal gas, potentially impeding lesion detection/delineation.

Goal(s): To evaluate a combined prospective-retrospective distortion reduction approach, based on distortion correction of female pelvic DWI acquired with reduced-FOV.

Approach: Two correction methods, RPG and Topup, were applied on images from cervical cancer patients and volunteers. Distortion correction performance was evaluated by the concordance between tumour/cervix borders in images before and after correction.

Results: Topup outperformed RPG, with statistically significant but modest improvements of initially small distortions resulting from the reduced-FOV acquisition. Occasional correction failures and limitations in the proton density correction warrant alternative approaches.

Impact: Topup distortion correction, commonly used for brain studies, shows statistically significant but modest improvements in female pelvic reduced-FOV DWI. Despite indications of clinical utility, limited improvements and occasional correction failures suggest alternative approaches and prospective distortion reduction as potential strategies.

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Abstract

Keywords