Abstract #2584

Characterization of Myocardial Microstructure using DT-CMR with Ultra-High-Performance Gradient Scanner in Healthy Subjects

Shi Chen¹, Danielle Kara¹, Thomas Garrett¹, Peyton Orlandi¹, Deborah Kwon^1,2,3, and Christopher Nguyen^1,2,3,4

¹Cardiovascular Innovation Research Center, Heart Vascular Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States, ²Cardiovascular Medicine, Heart Vascular Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States, ³Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ⁴Department of Biomedical Engineering, Case Western Reserve University and Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: Microstructure, Diffusion Tensor Imaging, Cardiac MRI, Healthy, Quantitative imaging

Motivation: DT-CMR has emerged as a promising tool for in vivo use in cardiovascular disease diagnosis, but there is currently a lack of reporting on the normal values for comparison.

Goal(s): Our goal was to evaluate the possibility of performing DT-CMR with an ultra-high-performance gradient MR scanner and provide normal ranges of quantitative DT-CMR measures.

Approach: Seventy healthy subjects underwent DT-CMR, and the results were compared between men and women.

Results: It is feasible to perform in vivo DT-CMR with a maximum gradient strength of 200 mT/m. The MD, FA and HAT for healthy subjects are (1.54±0.02) x10^-3mm²/s, 0.33±0.005 and -0.81±0.02 º/% respectively.

Impact: Our study reports on the initial experience of conducting DT-CMR on a new investigational ultra-high-performance gradient scanner. The normal ranges of quantitative DT-CMR values are instrumental to establish baseline and distinguish the diseased from healthy in the future.

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