Abstract #2587

Effect of tissues T1 content on the ADC values obtained with breast DWI using STIR fat-suppression

Denis Le Bihan^1,2, Mami Iima^3,4, Savannah C Partridge^5,6, Kazunori Kubota⁷, Kazunori Ohashi⁷, Masako Kataoka³, Mariko Goto², and Hiroko Satake⁸

¹NeuroSpin/Joliot, CEA-Saclay, Paris-Saclay University, Gif/Yvette, France, ²Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan, ³Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁴Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan, ⁵Radiology, University of Washington School of Medicine, Seattle, WA, United States, ⁶Breast Imaging, Seattle Cancer Care Alliance, Seattle, WA, United States, ⁷Radiology, Dokkyo Medical University Saitama Medical Center, Saitama, Japan, ⁸Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Synopsis

Keywords: Simulation/Validation, Diffusion/other diffusion imaging techniques, Fat suppression

Motivation: Fat signal suppression is essential for breast DWI as the very low diffusion coefficient of fat tends to decrease ADC values. STIR is a popular method, but signal suppression/attenuation is not specific to fat.

Goal(s): To show how ADC values obtained with STIR DWI may be biased toward tissue components with long T1s.

Approach: Results were obtained from simulations and data acquired in a dedicated breast DWI phantom made of vials with water and various concentration of PVP.

Results: ADC values obtained with STIR fat suppression may be over/under estimated depending on the T1 and ADC profile within tissues.

Impact: Fat suppression is essential for DWI. Among techniques STIR leads to low SNR and ADC misestimation depending on the tissues T1/ADC content, as STIR signal attenuation is not specific to fat. Other methods should be preferred, such as SPAIR.

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