Abstract #2588

The utility of diffusion kurtosis imaging in assessing immunoglobulin G4-related kidney disease: a feasibility study

Xiaoxiao Zhang¹, Gumuyang Zhang¹, Fei Teng², Zhuorui Xue², Lili Xu¹, Jiahui Zhang¹, Xin Bai¹, Li Chen¹, Qianyu Peng¹, Erjia Guo¹, Xuemei Li², Jinxia Zhu³, Grimm Robert⁴, Stemmer Alto⁴, Ke Zheng², Zhengyu Jin¹, and Hao Sun¹

¹Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ²Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ³MR Research Collaboration, Siemens Healthineers Ltd., Beijing, China, ⁴MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany

Synopsis

Keywords: DWI/DTI/DKI, Rare disease, Immunoglobulin G4; IgG4-related kidney disease

Motivation: Clinical diagnosis and assessment of immunoglobulin G4 (IgG4)-related disease is difficult. We explored whether diffusion kurtosis imaging (DKI) can resolve this difficulty.

Goal(s): To explore the feasibility of using DKI in the assessment of IgG4-related kidney disease (IgG4-RKD)

Approach: We measured the apparent diffusion coefficient (ADC) and DKI-derived parameters of the renal parenchyma, cortex, and medulla, then analyzed correlations between quantitative image parameters and clinical indicators.

Results: DKI-derived quantitative parameters were correlated with clinical indicators and demonstrated feasibility in the assessment of IgG4-RKD.

Impact: The DKI technique can help to detect IgG4-RKD lesions. DKI-derived quantitative parameters can assess IgG4-RKD clinical activity and facilitate evaluation of IgG4-RKD prognosis.

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