Keywords: Susceptibility/QSM, Head & Neck/ENT
Motivation: Identifying hypoxia in head and neck squamous cell carcinoma (HNSCC) could improve treatment. Quantitative susceptibility mapping (QSM) offers a potential method for measuring tissue composition and oxygenation.
Goal(s): To develop a robust, repeatable pipeline for QSM in the head and neck region.
Approach: We tested various QSM reconstruction pipelines and compared their intra- and inter-session repeatability, before applying an optimized pipeline to a HNSCC patient dataset.
Results: A pipeline using ROMEO phase unwrapping, V-SHARP background field removal, and iterative Tikhonov susceptibility calculation was found to be more repeatable than the previously reported best pipeline and showed nodal susceptibility differences in a HNSCC patient.
Impact: This new optimized pipeline provides repeatable susceptibility values in key ROIs through the head and neck region and detected nodal susceptibility differences in a HNSCC patient. Therefore, it is applicable for clinical studies of tissue susceptibility and oxygenation in HNSCC.
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