Keywords: Electromagnetic Tissue Properties, Ex-Vivo Applications, Genetic Diseases, Neurodegeneration, Iron
Motivation: Ex-vivo histology is the most common method to assess iron accumulation in frontotemporal lobar degeneration, but in vivo assessment is crucial to unravel disease mechanisms.
Goal(s): This study aims to assess the distribution and severity of iron accumulation post-mortem using susceptibility MRI and compare this to histological data.
Approach: We analyzed postmortem tissue of 5 MAPT-FTLD and 2 C9orf72-FTLD cases using a histological iron staining, T2*-weighted MRI, and QSM maps.
Results: We found that histology, susceptibility MRI, and QSM show good correspondence of iron distribution in FTLD brain tissue. However, sharp details are better seen on T2*-weighted MRI, and U-fibers on QSM maps.
Impact: Our study showed that susceptibility-based imaging can be used to visualize iron accumulation in FTLD; with T2*-weighted MRI and QSM showing complementary spatial information. Therefore, these two methods should be used parallel and not independent of each other.
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