Abstract #2624

Altered Interactive Dynamics of Neurofluids in Cerebral Small Vessel Disease

Chengxia Liu¹, Yuanhao Li¹, Wenhao Zhu¹, Shiqi Yang², Yuanyuan Qin¹, Tian Tian¹, Jiaxuan Zhang¹, Shun Zhang¹, and Wenzhen Zhu¹

¹Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China, ²School of Biomedical Engineering and Imaging, Xianning Medical College, Hubei University of Science and Technology, Xianning, China

Synopsis

Keywords: Neurofluids, Brain, neurofluids

Motivation: While changes of neurofluid dynamic has been observed in CSVD, the potential inter-correlations between them are still unclear.

Goal(s): Our goal was to demonstrate the potential interactive dynamics of neurofluids including the parenchyma perfusion, the glymphatic pathway, and the intracranial CSF in CSVD patients.

Approach: Parenchyma perfusion was assessed with pASL, glymphatic dynamics was assessed with DTI- ALPS, and CSF volume of ventricles was also quantified.

Results: The interactive dynamics of neurofluids of CSVD patients is significantly altered compared with that of normal elderly.

Impact: Disruption of neurofluid dynamics may play an important role in the pathophysiology of CSVD.

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