Keywords: Parkinson's Disease, Parkinson's Disease, Glymphatic Function, Peripheral Inflammation, DTI-ALPS
Motivation: The association between glymphatic system and peripheral inflammation has not been well studied.
Goal(s): Our study aimed to explore the relationship between glymphatic system and peripheral inflammation in PD patients and PD subtypes, and their link to motor symptoms.
Approach: We used DTI to calculate the DTI-ALPS index, a non-invasive measure of glymphatic function, and evaluated the association between the DTI-ALPS index and clinical parameters using multiple linear regression.
Results: Our study revealed a correlation between peripheral inflammation and glymphatic dysfunction in PD, particularly in TD subtype. Furthermore, the association between peripheral inflammation and clinical severity was observed in PD and PIGD patients.
Impact: This study provides new insights into the pathophysiology of PD and potential therapeutic options.
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