Keywords: Parkinson's Disease, Parkinson's Disease, Glymphatic dysfunction, Motor symptoms, Imaging biomarkers
Motivation: Growing evidence has shown that glymphatic dysfunction is closely linked to Parkinson’s disease(PD), yet its imaging in glymphatic system with motor symptoms remains unclear.
Goal(s): Using three different imaging metrics to validate the association of the glymphatic system with motor symptoms before and after administration of exogenous levodopa, and levodopa responsiveness in PD.
Approach: The calculation of DTI-ALPS index, the automated quantification of PVSs of basal ganglia region (BG-PVSs) and choroid plexus volume (CPV) based on MRI.
Results: When DTI-ALPS index decreases and BG-PVSs and CPV increase, motor symptom gets worsen and levodopa effectiveness diminishes. Significant linear correlations were observed (CPV-DTI-ALPS, CPV-PVSs, DTI-ALPS-PVSs).
Impact: This study employed three distinct imaging metrics (DTI-ALPS index, automated PVSs quantification, and CPV) to provide a more comprehensive characterization of the glymphatic system, affirming a correlation between glymphatic dysfunction and motor symptoms in Parkinson's patients.
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