Keywords: Motion Correction, fMRI
Motivation: 3D-EPI overcomes spatial resolution, spin-history and acceleration limitations of 2D-EPI but is rarely used for functional MRI (fMRI) due to its greater sensitivity to motion.
Goal(s): To examine the performance of our volumetric self-navigated (vSNav) 3D-EPI sequence for fMRI acquisition.
Approach: We acquired fMRI data using both our vSNav 3D-EPI and the standard 2D-EPI sequence during a block design finger tapping experiment both without and with intentional motion to compare the quality of the BOLD signal and the impact of different pre-processing steps.
Results: Although data quality was similar, 3D data were more robust to spatial smoothing.
Impact: A motion-robust 3D-EPI sequence will permit functional MRI with higher spatial and temporal resolutions. However, since the sequence acquires data and performs motion correction in a new way, it requires suitable preprocessing and analyses pipelines.
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