Keywords: Thermometry/Thermotherapy, Thermometry, Breast, Spectroscopic imaging
Motivation: Clinically available MR thermometry methods only measures relative temperature change. Availability of absolute temperature measurements has high impact potential to improve monitoring and evaluation of thermal therapies.
Goal(s): Develop an efficient and practical approach for spatial absolute MR thermometry in the breast.
Approach: A multi-echo echo-planar spectroscopic imaging pulse sequence was implemented and tested in ex vivo human breast fat samples and healthy volunteers. Comparisons to single voxel spectroscopy was performed.
Results: Water and fat peaks can be detected in both ex vivo samples and in vivo, and converted to absolute temperature measurements. Potential of spatial absolute thermometry is demonstrated.
Impact: Absolute MR thermometry has the potential to improve treatment monitoring and evaluation of thermal therapies, and is demonstrated in the breast using a new efficient high-resolution interleaved echo planar spectroscopic imaging pulse sequence.
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