Abstract #2713

Mild hyperthermia induced by MRgHIFU as an adjuvant to radiation therapy in bone metastases: preliminary results of a phase I study

Orane Lorton¹, Yacine M’Rad¹, Pauline Coralie Guillemin¹, Max Gau², Pelagia Tsoutsou², Thomas Zilli³, Pierre-Alexandre Poletti⁴, Rares Salomir^1,4, and Sana Boudabbous^1,5

¹University of Geneva, Faculty of Medicine, Geneva, Switzerland, ²Radio-oncology department, University Hospitals of Geneva, Geneva, Switzerland, ³Radiation Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland, ⁴Radiology department, University Hospitals of Geneva, Geneva, Switzerland, ⁵University Hospitals of Geneva, Geneva, Switzerland

Synopsis

Keywords: MR-Guided Focused Ultrasound, Focused Ultrasound, Hyperthermia, focused ultrasound, bone metastasis

Motivation: Mild hyperthermia (HT) induced by magnetic resonance-guided focused ultrasound (MRgHIFU) before radiation therapy (RT) could act as adjuvant in pain relief for bone metastasis.

Goal(s): This study aims to evaluate the feasibility and safety of MRgHIFU procedure in one patient with a posterior right acetabulum

Approach: The target temperature elevation was 6°C. The targeting and temperature monitoring in near real-time were performed by MRI.

Results: The temperature elevation lasting 30-minutes was 6.01°C on average in bone metastasis. The MR-guidance allowed a safe and successful procedure without adverse events. The 25-minutes between HT end point and RT demonstrated the technical feasibility of the procedure.

Impact: This study is a first step to demonstrate MRgHIFU hyperthermia adjuvant to palliative radiotherapy of bone metastases. The non-invasive, safe and accurate use of focused ultrasound to sensitize tumors opens the way to more efficient application of the radiation dose.

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