Keywords: MR-Guided Focused Ultrasound, Focused Ultrasound, 2-photon microscopy
Motivation: The gold-standard for confirmation of blood-brain barrier (BBB) disruption after FUS is T1-weighted MRI with contrast enhancement. Conventional MRI-based metrics cannot differentiate between BBB leakage at the microvascular level, and thus there is a need for validation with higher spatial and temporal resolution modalities
Goal(s): Use 2-photon microscopy to investigate solute extravasation from the microvasculature into the parenchyma and paravascular space.
Approach: This project is an in-vivo validation of BBB opening after FUS using 2-photon microscopy and MRI.
Results: Results suggest BBB opening occurs in capillaries, and that dye extravasation can be measured within minutes of sonication.
Impact: Sub-micron imaging of the microvasculature after BBB opening will provide insight into which vessels are opened after FUS and improve pharmacokinetic understanding of the paravascular space around arterioles and venules.
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