Abstract #2726

Analyzing the Impact of Transcranial Direct Current Stimulation on the Human Primary Visual Cortex through fMRI-based Brain Entropy

Rui Qian¹, Yifan Shuai¹, Chengjiaao Liao¹, Yangling Zhou¹, Shaomin Zhang², Dan Wu¹, Minmin Wang², and Zhiyong Zhao¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Other Interventional, fMRI (resting state), Brain Entropy, tDCS

Motivation: Specific impact of Transcranial Direct Current Stimulation (tDCS) on the human primary visual cortex (V1) remains unclear.

Goal(s): We used fMRI-based brain entropy (BEN) method to investigate the effects of short- and long-term tDCS on brain activity, and dynamic changes of BEN during tDCS.

Approach: The resting-state fMRl data were collected before, during and after stimulation from 10 healthy subjects.

Results: We observed reduced BEN values after both short- and long-term tDCS in frontoparietal and occipital areas. During tDCS, the brain preferred to stay in a state with lower BEN values in the default mode network compared to other brain regions.

Impact: Short- and long-term tDCS on V1 both have a positive effect on improving cognitive functions in healthy and psychiatric disorder population. We also further validated the utility of BEN as an effective method for assessing tDCS effects.

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