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Abstract #2755

The effect of fasting on renal phase contrast and arterial spin labelling

Bashair Alhummiany1, David L. Buckley1, David Shelley2, Kanishka Sharma3,4, and Steven Sourbron4
1Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 2Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 3Antaros Medical AB, Mölndal, Sweden, 4The University of Sheffield, Sheffield, United Kingdom

Synopsis

Keywords: Kidney, Kidney, Renal blood flow, Perfusion, Phase contrast, Arterial spin labelling

Motivation: Variations in dietary conditions can impact renal blood flow (RBF), but it is currently unknown whether fasting overnight can affect the measurement. A recent consensus for phase contrast (PC) advises against fasting, but similar consensus for arterial spin labelling (ASL) was not reached. Other laboratory tests might require fasting, leading to variability in preparation for MRI. It is therefore critical to understand whether fasting affects the measurement

Goal(s): This study investigates the effect of fasting compared to the recommended MRI preparation.

Approach: ASL and PC acquired in healthy volunteers.

Results: No significant difference between fasting and consensus-preparation was found for RBF and perfusion.

Impact: A strict control for diet may not be required for MRI studies measuring renal blood flow and perfusion using phase contrast and arterial spin labelling.

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Keywords