Abstract #2758

Combining ASL and MRE to Investigate the Impact of Perfusion on Renal Stiffness in Patients with CKD: A Preliminary Study

Yueyao Chen¹, Peiyin Luo¹, Ruirui Qi¹, Qiuyi Chen¹, Junfeng Li¹, Qiumei Liang¹, Wenxi Liu², Haodong Qin³, bernd kuehn⁴, Fanqi Meng¹, Hanqing Lyu¹, Jingtong Pan¹, Feifei Qu⁵, and Yanglei Wu⁶

¹Department of Radiology, Shenzhen Traditional Chinese Medicine Hospital (The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine), Shenzhen, China, ²Shenzhen University, Shenzhen, China, ³MR Research Collaboration, Siemens Healthineers, Guangzhou, China, ⁴MR Application Predevelopment, Siemens Healthineers AG, Erlangen, Germany, ⁵MR Research Collaboration, Siemens Healthineers, Shanghai, China, ⁶MR Research Collaboration, Siemens Healthineers, Beijing, China

Synopsis

Keywords: Kidney, Arterial spin labelling, Magnetic resonance elastography, chronic kidney disease, perfusion assessment, renal stiffness

Motivation: The impact of renal perfusion on stiffness values is yet to be conclusively validated, which has hindered the diagnostic application of magnetic resonance elastography (MRE) in patients with chronic kidney disease (CKD).

Goal(s): To explore the characteristics of renal perfusion and stiffness values in patients with CKD and their correlation.

Approach: Renal MRE and arterial spin labeling (ASL) were used to measure renal stiffness and blood flow. The study employed t-test, receiver-operating characteristic curves, and Spearman correlation for data analysis.

Results: The two techniques were effective in diagnosing CKD, simultaneously confirming the influence of perfusion factors on stiffness.

Impact: This preliminary human study further supported the correlation between renal stiffness and perfusion, supporting the enhanced diagnostic efficacy of combining MRE and ASL for CKD, thus facilitating staging.

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