Keywords: Lung, Lung, Mid-field
Motivation: Pulmonary perfusion imaging requires ionizing radiation (CT) or gadolinium-based contrast agents (MR) and therefore cannot be used on all patients.
Goal(s): We propose an easy-to-prescribe non-contrast pulmonary perfusion imaging method to improve the diagnosis and monitoring of pulmonary hypertension.
Approach: We designed a free-breathing arterial spin labeling imaging sequence that is compatible with whole-lung coverage at 0.55T. We demonstrate this method in healthy volunteers and a swine model.
Results: We measured 11.55±4.09% and 7.76±2.62% ASL signals using inversion and saturation labeling which was comparable between breath-held and free-breathing scans. Perfusion defects were clearly visualized in the swine model.
Impact: Our method should enable qualitative assessment of non-contrast pulmonary perfusion in patients who are contraindicated for gadolinium-based contrasts or who need frequent monitoring of pulmonary perfusion. Our method would contribute to enabling contrast-free comprehensive pulmonary exams at 0.55T.
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