Abstract #2762

Effect of Bronchodilator Treatment on Pulmonary Artery Pulse Wave Velocity in COPD measured with PREFUL MRI

Marius M Wernz^1,2, Andreas Voskrebenzev^1,2, Robin Müller^1,2, Maximilian Zubke^1,2, Filip Klimeš^1,2, Jens Hohlfeld^2,3, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in End-stage and Obstructive Lung Disease Hannover, German Center for Lung Research, Hannover, Germany, ³Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany

Synopsis

Keywords: Lung, Lung

Motivation: Vascular stiffness and secondary pulmonary hypertension in COPD are common. Noninvasive measurement of pulse wave velocity as a marker of arterial stiffness by PREFUL MRI is feasible. The effect of bronchodilators on PWV is unclear.

Goal(s): To determine the effect of bronchodilators on pulmonary artery stiffness as measured by PWV derived using PREFUL MRI.

Approach: PREFUL MRI in 52 patients before and after placebo-controlled bronchodilator treatment.

Results: In patients with elevated PWV, a significant decrease in PWV was measured after treatment. In the placebo control period and in the patients with normal baseline PWV, no significant changes were observed.

Impact: Pulmonary artery stiffness can be measured by PREFUL MRI-based pulse wave velocity (PWV) calculation. PREFUL MRI is a promising tool to monitor PWV changes after bronchodilator treatment.

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