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Abstract #2859

Assessment of Glymphatic Function in Acute High Altitude Reaction: by diffusion tensor image analysis along the perivascular space (DTI-ALPS)

Ya Guo1, HaiHua Bao1, Shengbao Wen1, Tao Tao1, Changyou Long1, Shaoxin Xiang2, Yuxin Yang2, and Shipei He2
1Department of Medical Imaging Center, Qinghai University Affiliated Hospital, Xining, China, 2United Imaging Research Institute of Intelligent Imaging, Beijing, China

Synopsis

Keywords: DWI/DTI/DKI, Brain, Diffusion tensor image analysis along the perivascular space (DTI-ALPS),Acute high altitude reaction

Motivation: Diffusion tensor image analysis along the perivascular space(DTI-ALPS) is a novel non-invasive assessment of the activity of the human brain's lymphoid system, which is currently being used to assess the function of the lymphoid system in patients with acute high altitude reaction(AHAR).

Goal(s): To evaluate the activity of the glymphatic system in patients with AHAR using DTI-ALPS, and explore the relationship between lymphoid function and disease severity.

Approach: Recruited 5 patients with AHAR and calculated ALPS index, Pearson correlation analysis were used for evaluating relationship between ALPS index and diagnostic scoring.

Results:

There was a significant correlation between DTI-ALPS and disease scores(r=-0.964 P=0.005).

Impact: DTI-ALPS is a novel non-invasive assessment of the activity of the human brain's lymphoid system, which is currently being used to assess the function of the lymphoid system in patients with AHAR.

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