Keywords: DWI/DTI/DKI, Diabetes
Motivation: T2DM has emerged as an important risk factor for cognitive impairment. However, the neuropathological basis of the cognitive impairment associated with T2DM is still unclear.
Goal(s): To investigate whether the impaired glymphatic function is one of the mechanisms in T2DM-associated cognitive dysfunction.
Approach: We compared the glymphatic function by calculating the diffusion along the perivascular space based on a diffusion tensor image, namely the DTI-ALPS index between HCs and patients with T2DM and investigated the relationship between DTI-ALPS index and cognitive functions.
Results: The lower DTI-ALPS index was found in patients with T2DM, and DTI-ALPS index was correlated with worse cognitive performance.
Impact: DTI-ALPS index may be applied as a useful indicator to evaluate the glymphatic system function. The impaired glymphatic system in patients with T2DM may provide a new perspective for understanding the pathophysiology of T2DM related cognitive impairment.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords