Abstract #2861

Relationship Between Apparent Fiber Density in Corpus Callosum and Cognitive Function.

Naoya Hayashi^1,2, Daisuke Yoshimaru^3,4, Shuhei Shibukawa^3,5, Eri Arizono³, Yoichi Araki¹, Naoki Kawaguchi¹, Soichiro Shimizu⁶, and Kazuhiro Saito³

¹Department of Radiology, Tokyo Medical University Hospital, Tokyo, Japan, ²Department of Radiological Sciences, Graduate School of Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, ³Department of Radiology, Tokyo Medical University, Tokyo, Japan, ⁴Division of Regenerative Medicine, Jikei University School of Medicine, Tokyo, Japan, ⁵Department of Radiological Technonlogy, Faculty of Health Science, Juntendo University, Tokyo, Japan, ⁶Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan

Synopsis

Keywords: DWI/DTI/DKI, Diffusion Tensor Imaging

Motivation: Evaluation of fiber density in the corpus callosum (CC) is expected to show a higher sensitivity in relation to cognitive function than changes in volume.

Goal(s): The goal is to clarify the association between the volume and AFD of the CC5 region and neuropsychological test scores.

Approach: We examined the relationship between neuropsychological test scores, and calculated AFD and CC volume for 180 patients with suspected dementia.

Results: CC volume showed no significant association with neuropsychological test scores. On the other hand, AFD showed associations with several neuropsychological tests.

Impact: This study demonstrated that AFD correlated better with cognitive function than the previously reported CC volume. It was indicated the superior sensitivity of AFD in assessing cognitive function in dementia diagnosis.

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