Keywords: DWI/DTI/DKI, COVID-19
Motivation: The prevalence of the SARS-CoV-2 Omicron variant poses a significant concern. It is important to investigate its potential repercussions on public health.
Goal(s): To evaluate the impacts of Omicron variant on white matter microstructure.
Approach: Diffusion MRI data were acquired on young adults tested positive for COVID-19 antigen or nucleic acid within two months and with non-hospitalized mild symptoms during infection. Tract-wise DTI metrics were used to quantify microstructural properties.
Results: SARS-CoV-2 infection leads to significant short-term microstructural changes in the white matter, which exhibit spatial and gender disparity.
Impact: This study provides evidence for short-term microstructural changes induced by SARS-COV-2 Omicron variant infection, which motivates further investigation to uncover the mechanisms by which viruses invade the nervous system.
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