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Abstract #2889

The Effect of Age and BMI In Renal mpMRI With Regional Analysis

Luis Carlos Sanmiguel1,2,3, Pieter De Visschere1,2, and Pim Pullens1,3,4
1Department of Radiology and Nuclear Medicine, Ghent University Hospital, Gent, Belgium, 2Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Gent, Belgium, 3Ghent Institute of Functional and Metabolic Imaging (GIFMI), Ghent University, Gent, Belgium, 4IBiTech– Medisip, Ghent University, Gent, Belgium

Synopsis

Keywords: Kidney, Kidney, ASL, DWI, ADC, Perfusion, Age, BMI

Motivation: The demand for accurate and non-intrusive renal function evaluation methods.

Goal(s): To discern how age and BMI affect:

  • Renal perfusion measured with ASL (Arterial spin labeling).
  • Renal diffusion measured with Apparent diffusion coefficient (ADC) from DWI (Diffusion-weighted images).

Approach:

  1. Recruit and scan healthy volunteers.
  2. Create a database with the results.
  3. Apply statistics:
  • Evaluating correlations (Spearman coefficient).
  • Evaluating differences between groups (Mann-Whitney U test).

Results:
ASL:

  • Negative significant age-related perfusion and significant differences between age groups.
  • Negative significant correlations of BMI with perfusion in inner regions of the kidneys.
ADC:
  • No significant correlation with age.
  • Negative significant correlations of BMI with ADC maps.

Impact: These findings provide insights for the MRI community, enhancing tailored renal understanding and diagnostic precision. Personalized approaches, using age and BMI, have the potential to enhance patient outcomes. This study encourages focused research, promoting personalized medicine and refining renal imaging.

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Abstract

Keywords