Keywords: Kidney, Quantitative Imaging, type 2 diabetes mellitus; IDEAL-IQ; proton-density fat fraction; diabetic kidney disease
Motivation: Renal parenchymal fat deposits play a crucial role in the development of diabetic kidney disease (DKD). Noninvasive measurement of renal parenchymal fat deposits using functional MRI provides valuable insights into the pathogenesis of DKD.
Goal(s): Exploring the reproducibility of IDEAL-IQ imaging in quantifying renal lipid deposition and to investigate the differences observed in DKD patients.
Approach: A total of 26 healthy participants underwent two IDEAL-IQ scans without repositioning and 96 type 2 diabetes mellitus (T2DM) patients underwent a single IDEAL-IQ scan.
Results: IDEAL-IQ imaging is a reproducible technique for noninvasively quantifying renal lipid deposition. Furthermore, the technique shows promising performance in staging DKD.
Impact: This study highlights the potential benefits of IDEAL-IQ imaging in evaluating renal lipid deposition in DKD patients. It contributes to a better understanding of the pathogenesis and progression of DKD, to improved diagnostic and management strategies for T2DM patients.
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