Abstract #2895

Initial experience of combined microstructural and functional magnetic resonance imaging for the characterisation of renal tumours.

Richard Hesketh¹, Timothy Bray¹, Snigdha Sen², Lorna Smith¹, Rafat Chowdhury¹, Adam Retter¹, Lucy Caselton¹, David Atkinson¹, Eleftheria Panagiotaki², Fiona Gong¹, Max Bullock¹, Joey Clemente¹, Maxine Tran³, and Shonti Punwani¹

¹Centre for Medical Imaging, University College London, London, United Kingdom, ²Centre for Medical Imaging Computing, UCL, London, United Kingdom, ³Department of Surgical Biotechnology, UCL, London, United Kingdom

Synopsis

Keywords: Kidney, Cancer, Hyperpolarised MRI, renal cancer, VERDICT

Motivation: Accurate differentiation of renal tumour subtype and grade is not currently possible using standard of care imaging.

Goal(s): To use combined functional and microstructural MRI in the form of diffusion weighted imaging with VERDICT, proton density fat fraction and hyperpolarised [1-13C]pyruvate to detect the different histological and metabolic features of different renal tumours.
Two patients with histologically proven renal tumours (grade 2 clear cell and grade 3 papillary) underwent MRI imaging.

Approach: Two patients with histologically proven renal tumours (grade 2 clear cell and grade 3 papillary) underwent MRI imaging.

Results: Combined function and microstructural MRI differentiated tumour types and normal kidney.

Impact: This study demonstrates the first combined use of VERDICT, PDFF and hyperpolarised [1-13C]pyruvate. The differentiation of renal tumours has proven difficult on imaging and this combination is a promising approach to this significant clinical problem.

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