Abstract #2905

Pulmonary function in sarcoidosis: Comparison between matrix pencil decomposition MRI at 0.55T and lung function tests

Maurice Pradella¹, Hanns-Christian Breit¹, Oliver Bieri^2,3, Michael Bach¹, Jens Bremerich¹, Katrin Esther Hostettler⁴, and Grzegorz Bauman^2,3

¹Department of Radiology, University Hospital of Basel, Basel, Switzerland, ²Division of Radiological Physics, Department of Radiology, University Hospital of Basel, Basel, Switzerland, ³Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland, ⁴Clinic of Respiratory Medicine, University Hospital of Basel, Basel, Switzerland

Synopsis

Keywords: Lung, Lung, Low-field

Motivation: Sarcoidosis is a systemic inflammatory disease in particular affecting lung tissue, thus there is a need for non-invasive and ionizing radiation free technique to assess regional lung function.

Goal(s): To examine correlations between functional lung MRI and pulmonary lung function tests in patients with sarcoidosis.

Approach: Lung ventilation and perfusion was assessed using matrix pencil decomposition MRI at a low-field 0.55T MR-scanner in sarcoidosis patients and a control group of healthy volunteers. Conventional lung function tests in patients were performed with spirometry and body plethysmography.

Results: Strong correlations between the functional lung MRI and the metrics from conventional pulmonary function tests were observed.

Impact: To our knowledge, this is the first study focused on the evaluation of lung function using MRI in sarcoidosis patients. Our results support the use of MRI as a non-invasive diagnostic tool to assess lung function in patients with sarcoidosis.

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