Keywords: Lung, COVID-19
Motivation: It is unclear the extent to which abnormal lung ventilation is present in long COVID subjects without prior respiratory diseases.
Goal(s): Evaluate 129Xe lung ventilation imaging in a cohort without prior respiratory disease, consisting of patients with long COVID (with and without dyspnea) and controls.
Approach: 60 patients with long COVID (53 with dyspnea, 7 without dyspnea) and 20 controls underwent successful ventilation imaging and were included in analysis.
Results: 129Xe ventilation imaging metrics did not find significant differences between controls and patients with long COVID, however a subset of long COVID patients with dyspnea had lung ventilation defects despite normal PFTs.
Impact: Impact (40 words): The majority of patients with long COVID have normal 129Xe lung ventilation imaging. 129Xe ventilation imaging may be able to identify candidates with long COVID who may be candidates for treatments targeted at airways disease.
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