Abstract #2920

Correlation Between Cortical Thickness and Motor Functions in Individuals with Cerebral Small Vessel Disease Burdens

pengcheng liang¹, lingfei guo¹, changhu liang¹, meng li², jing li³, yian gao¹, chaofan sui¹, yiwen chen¹, and zhenyu cheng⁴

¹Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, jinan, China, ²Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Jena-Magdeburg-Halle, Germany, ³Department of Radiology, Beijing Tsinghua Changgung Hospital, beijing, China, ⁴School of Medical Imaging, Binzhou Medical University, No. 346 Guanhai Road, Yantai, jinan, China

Synopsis

Keywords: Gray Matter, Gray Matter, Cerebral small vessel disease, timed up and go, cortical thickness, motor impairment, right insular cortex

Motivation: Delve into the cortical territories most vulnerable to cerebral small vessel disease (CSVD)

Goal(s): Determine the pivotal cortical zones that play a crucial role in mediating motor dysfunction in patients affected by CSVD, and scrutinize the risk factors that could potentially influence these pertinent cerebral areas.

Approach: Cortical thickness measurements were acquired utilizing an integrated approach of magnetic resonance imaging (MRI) and FreeSurfer technology.

Results: The right insular cortex holds a crucial position in the cascade of motor impairments observed in individuals diagnosed with CSVD. Body Mass Index (BMI) emerges as a potentially vital risk factor.

Impact: Focusing on the cortical thickness of the right insular cortex in individuals with CSVD and the risk factors that influence it (such as BMI) may lead to a better understanding and early intervention for motor impairment in individuals with CSVD.

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