Abstract #2926

Brain gray matter alterations in individuals with convergence insufficiency

Yuxia Wang^1,2, Ye Wu³, Yanglei Wu⁴, Huaiqiang Sun¹, and Fei Li¹

¹Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China, ²Department of Radiology, Suining Central Hospital, Suining, Sichuan 629099, China, ³Department of Ophthalmology, Laboratory of Optometry and Vision Sciences, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China, ⁴MR Research Collaboration, Siemens Healthineers, Beijing, China

Synopsis

Keywords: Gray Matter, Nervous system, Convergence insufficiency;Brain;Structure

Motivation: Whether abnormal visual experiences in individuals with convergence insufficiency (CI) would be associated with brain structural alterations.

Goal(s): To explore altered cortical structural characteristics in individuals with CI and its relationship with visual measures and clinical symptoms.

Approach: All participants underwent high-resolution T1-weighted brain magnetic resonance imaging scanning and cortical thickness, surface area, and volume were calculated and compared between two groups.

Results: There are altered cortical gray matter volume and surface area in the brain regions related to the function of eye movement in CI than healthy controls, one of which was correlated with near point of convergence.

Impact: Our results shed light on the impact of binocular vision dysfunctions on human brain structure, explicate the neural mechanism of CI, and reveal the potential utility of brain MRI in assessing the neural mechanism of ocular diseases.

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