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Abstract #2933

Visualization of Human Brain Cortical Layers Using Quantitative Parameter Mapping on a 3 Tesla Scanner

Yuki Kanazawa1, Yo Taniguchi2, Masafumi Harada1, Kosuke Ito2, and Yoshitaka Bito2
1Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan, 2FUJIFILM Healthcare Corporation, Tokyo, Japan

Synopsis

Keywords: Gray Matter, Microstructure

Motivation: To observe the cortical layer in detail using MRI.

Goal(s): To evaluate the visualization of cortical layers in humans using quantitative parameter mapping (QPM)-MRI.

Approach: Using T1, T2, and R1·R2* derived from QPM-MRI, each measured value in the motor cortex and the putamen was compared. Additionally, the line profile curves of the cortex for R1, R2* and R1·R2* images were plotted.

Results: There are significant differences between the motor cortex and the putamen in T1 and T2* (P < 0.05). Visualization using R1·R2* leads to emphasis on the susceptibility effect of iron and myelin in addition to T1 differences.

Impact: Visualization using R1·R2* derived from QMP-MRI leads to emphasis on the susceptibility effect of iron and myelin in addition to T1 differences based on myelin content in the cortex.

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Keywords