Keywords: Multiple Sclerosis, Multiple Sclerosis, Disease Duration; Substantia nigra; Iron; Swallow tail sign; Quantitative susceptibility mapping
Motivation: Regionally progressive iron deposition has not been indicated in the substantia nigra (SN), which is the main impaired region in relapsing-remitting multiple sclerosis (RRMS).
Goal(s): To study the iron accumulation in substantia nigra (SN) subdivisions and “swallow tail sign” in RRMS patients with different DDs.
Approach: Quantitative susceptibility mapping (QSM) values were measured in the anterior and posterior SN at different levels.
Results: QSM values of the SN were higher in RRMS patients with 5-10 years DDs than controls. There were significantly positive correlations between “swallow tail sign” scores and QSM values of the caudal pSN in the patients with long DDs.
Impact: This is a preliminary study providing objective evidence of the iron-related progression of SN subregions in RRMS patients with different DDs, and abnormal “swallow tail sign” may provide an additional imaging maker for MS patients.
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