Keywords: Multiple Sclerosis, Multiple Sclerosis
Motivation: Disease progression is variable in multiple sclerosis (MS). Widely-used measures of neuropathology do not show a straightforward relationship to functional decline.
Goal(s): Our work aims to identify changes in brain function that are related to MS disease progression.
Approach: We measured resting state functional connectivity MRI at 7 tesla in 71 adults with MS. We compared cortical grey matter regional homogeneity (ReHo) in participants with early and late stage MS and correlated ReHo with MS disease severity.
Results: Local connectivity, measured by ReHo, was stronger in early MS and was related to disease severity.
Impact: MRI-based measures that track and predict MS disease progression could identify patients who subsequently decline and serve as outcome measures in clinical trials of novel disease modifying treatments.
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