Abstract #2960

Current Stimulation and Brain Connectivity in Prodromal Multiple Sclerosis: A Simultaneous tDCS-MRI Study

Marco Muccio^1,2, Giuseppina Pilloni³, Luis Fernandez³, Erica Kreisberg³, Lauren Krupp³, Abhishek Datta⁴, Marom Bikson⁵, Leigh Charvet³, and Yulin Ge^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York City, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York City, NY, United States, ³Neurology, New York University Grossman School of Medicine, New York City, NY, United States, ⁴Research and Development, Soterix Medical Inc, Woodbridge Township, NJ, United States, ⁵Biomedical Engineering, City College of New York, New York City, NY, United States

Synopsis

Keywords: Multiple Sclerosis, Neurodegeneration

Motivation: The extent of tDCS’s impact on brain functional connectivity(FC) in individuals with prodromal multiple sclerosis(MS) remains largely unknown.

Goal(s): To investigate the acute tDCS effects on brain network and FC using resting state functional MRI(rs-fMRI) in MS prodromal patients.

Approach: The study involved a concurrent tDCS-MRI session, in which rs-fMRI data were acquired prior to and during tDCS (2mA, DLPFC left anodal).

Results: During tDCS, we noted a significant increase in FC between hippocampus and frontal pole as well as lateral parietal cortex in the left hemisphere. Similar increases were observed between frontal left regions and cortical and subcortical areas.

Impact: The observed effects of tDCS on brain network dynamics and resting state functional connectivity in prodromal MS could potentially influence its future clinical applications as a treatment option in such early stages of the disease.

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